Salicylic Acid

Class: Keratolytic Agents
ATC Class: D01AE12
VA Class: DE500
CAS Number: 69-72-7
Brands: Aveeno Clear Complexion, Clearasil, Compound W, Denorex, Dermarest, DHS Sal, Dr Scholl’s, DuoFilm, Freezone, Hydrisalic, Ionil Plus, Keralyt, Kerasal, Mediplast, Meted, MG 217 Sal-Acid, Neutrogena Rapid Clear, Neutrogena T-Sal, Noxzema, Occlusal, Oxy, P&S, Psoriasin, Sal-Acid, Salactic, Salex, Sal-Plant, Sebasorb , Stridex, Tarsum , Trans-Ver-Sal, Versiclear, Wart-off

Introduction

Keratolytic agent; derivative of benzoic acid.^{a o}

Uses for Salicylic Acid

Acne

Salicylic acid is used alone or in combination with other drugs (e.g., resorcinol, sulfur) for the symptomatic treatment of acne.^{a c k}

Seborrheic Dermatitis and Psoriasis

Salicylic acid is used for self-medication to control seborrheic dermatitis of the body and scalp, psoriasis of the body and scalp, dandruff, and other scaling dermatoses.^{a f l m o q r s}

Cream, lotion, and gel (6% salicylic acid) used to aid in the exfoliation of dry, scaly skin associated with psoriasis.^{l o p}

Hyperkeratosis

Salicylic acid is used topically as self-medication for its keratolytic and caustic effect in the removal of common and plantar warts;^{a d h j l} also used to remove corns and calluses.^{a e i n o p}

Salicylic acid is used for treatment of localized hyperkeratosis that occurs on the palms and soles.^{a l o}

Tinea Versicolor

Salicylic acid is used in combination with an antifungal (sodium thiosulfate) for the treatment of tinea versicolor (Malassezia furfur) infection.^g

Salicylic Acid Dosage and Administration

General

• 
  

  Consult a clinician prior to initiating self-medication for a condition that covers a large area of the body.^{f m q r}

  
  

Administration

Topical Administration

Apply topically to the skin as a cake, cream, gel, lotion, ointment, pledget, plaster, shampoo, or solution.^{h i j k l m n o q r s t}

For external use only;^{c d e f h i j k} not for ophthalmic, oral, or intravaginal use.^{l o p} If contact with the eye(s) occurs, wash thoroughly with water.^{d e f h k m n q r}

Rinse hands thoroughly after topical application, unless hands are being treated.^{l o p}

Do not use systemically because of severe irritating effect on GI mucosa and other tissues.^{a b}

Apply salicylic acid 6% cream (Salex), lotion (Salex), or gel (Keralyt, Hydrisalic) topically to affected area(s) at bedtime.^{l o p} Hydrate affected area of skin (e.g., with wet packs or baths) for ≥5 minutes prior to application and cover with occlusive dressing.^{l o p} In the morning, wash affected area of skin; may apply a bland emollient if affected skin is irritated or excessively dry.^{l o} If occlusion is not possible, may apply more frequently.^{l o p} However, excessive, repeated application does not necessarily increase therapeutic benefit and may increase risk of adverse local effects and salicylism.^l (See Salicylate Toxicity under Cautions.)

Acne (Self-medication)

Apply topically using appropriate preparations containing salicylic acid 0.5–2%.^c

Cleanse and dry the affected area prior to topical application.^c

Apply a thin layer of appropriate salicylic acid preparation (e.g., cream, gel, lotion) to affected areas.^c

Apply cake or cleansing solution with water, in place of regular soap; rinse thoroughly with warm water and pat dry.^{c k}

Seborrheic Dermatitis and Psoriasis (Self-medication)

Apply topically using appropriate preparations containing salicylic acid 1.8–3%.^f

Apply cream, lotion, ointment, gel, or solution to affected areas of skin.^f

Apply preparations formulated as soaps or shampoo to affected area(s) in place of regular soap or shampoo.^{f m}

Hyperkeratosis

Corn and Callus Removal (Self-medication): Apply topically using appropriate preparations containing salicylic acid 12–40% (e.g., plaster, solution in flexible collodion) or 3% (gel).^e

Do not apply on irritated or infected skin.^{e n}

Cleanse and dry the affected area prior to topical application.^{e i n}

Trim plaster to fit completely over the callus or corn and apply.^{e i}

Apply a small amount of solution in flexible collodion with an applicator to sufficiently cover corn or callus and allow to dry.^{e n}

Apply a small amount of solution or gel (e.g., 1 drop at a time) with an applicator to sufficiently cover corn or callus; allow to dry.^{e h}

May soak affected area(s) in warm water for 5 minutes to aid in corn or callus removal.^{e i n}

Wart Removal (Self-medication): Apply topically using appropriate preparations containing salicylic acid 12–40% (plaster) or 5–17% (solution in flexible collodion).^{d h j}

Do not use on moles, birthmarks, warts with hair(s) growing from them, genital warts, or warts on the face or mucous membranes.^{d h j}

Do not apply on irritated, reddened, or infected skin.^d

Cleanse and dry the affected area prior to topical application; may soak affected area(s) in warm water for 5 minutes.^d

Trim plaster to fit completely over the wart and apply.^{d j}

Prior to application of plaster in a karaya gum and polyethylene glycol vehicle (Trans-Ver-Sal), gently smooth wart with emery board, and carefully apply a drop of warm water to wart, using a cotton-tipped applicator. Trim plaster to completely fit over wart; if necessary, secure plaster in place with medical tape.^j Ensure that the plaster does not touch unaffected surrounding skin.^j

Apply a small amount of solution or gel (e.g., one drop at a time) with an applicator to sufficiently cover wart(s); allow to dry.^{d h}

Dosage

Pediatric Patients

Acne

Topical

Self-medication: Apply appropriate 0.5–2% salicylic acid preparation 1–3 times daily.^c Initially, apply once daily, then gradually increase to 2 or 3 times daily, if necessary.^c If dryness or peeling occurs, reduce application to once daily or every other day.^c

Seborrheic Dermatitis and Psoriasis

Scalp

Topical

Self-medication for children >2 years of age: Apply 3% salicylic acid solution to affected area(s) of the scalp 1–4 times daily or as directed by a clinician.^{f s}

Apply 2–3% salicylic acid shampoo to wet hair and massage into scalp.^m Leave lather on scalp for 2 minutes, then rinse thoroughly; repeat if necessary.^m Use at least twice weekly or as directed by a clinician.^{f m}

Apply combination (salicylic acid and coal tar) shampoo to scalp evenly before bathing.^u Allow to remain on scalp for 5 minutes; add water and lather, and then rinse thoroughly.^u Gradually increase treatment times to 1 hour, or as directed by a clinician.^u Alternatively, apply to wet hair and lather; allow to remain on scalp for up to 10 minutes, then rinse.^u Use daily until itching and flaking improve, then reduce to twice weekly or as directed by a clinician.^u

Body (Excluding Scalp)

Topical

Self-medication for children >2 years of age: Apply appropriate 1.8–3% salicylic acid preparation (e.g., cream, ointment, lotion, gel) to affected area(s) 1–4 times daily or as directed by a clinician.^{f q r}

Apply 2–3% salicylic acid shampoo to affected area(s) of the body in place of soap.^m Leave lather on for 2 minutes, then rinse thoroughly; repeat if necessary.^m Use at least twice weekly or as directed by a clinician.^{f m}

Children ≥2 years old: Apply 6% salicylic acid gel, cream, or lotion to affected area(s) once daily at bedtime and occlude.^{l o p} When improvement occurs, apply occasionally to maintain remission.^{l o p} In areas where occlusion is difficult or impossible, apply more frequently.^{l o p}

Hyperkeratosis

Corn and/or Callus Removal

Topical

Children ≥2 years of age: Apply 6% salicylic acid gel, cream, or lotion to affected area(s) once daily at bedtime and occlude.^{l o p} In areas where occlusion is difficult or impossible, apply more frequently.^o

Self-medication for children >12 years of age: Apply 3% salicylic acid gel to calloused skin once daily or as directed by a clinician.^t

Wart Removal

Topical

Children ≥2 years of age: Apply 15% salicylic acid plaster in a karaya gum and polyethylene glycol vehicle once daily at bedtime; leave in place for ≥8 hours, then remove and discard.^{d j} Repeat every 24 hours as needed until wart is completely removed or for up to 12 weeks.^{d j}

Tinea Versicolor

Topical

Children >12 years of age: Apply combination lotion (salicylic acid 1% and sodium thiosulfate 25%) in a thin film to all affected area(s) twice daily or as directed by a clinician.^v

Adults

Acne

Topical

Self-medication: Apply appropriate 0.5–2% salicylic acid preparation 1–3 times daily.^c Initially, apply once daily, then gradually increase to 2 or 3 times daily, if necessary.^c If dryness or peeling occurs, reduce application to once daily or every other day.^c

Seborrheic Dermatitis and Psoriasis

Scalp

Topical

Self-medication: Apply 3% salicylic acid solution to affected area(s) of the scalp 1–4 times daily or as directed by a clinician.^{f s}

Self-medication: Apply 2–3% salicylic acid shampoo to wet hair and massage into scalp.^{f m} Leave lather on for several minutes, then rinse thoroughly; repeat if necessary.^{f m} Use at least twice weekly or as directed by a clinician.^{f m}

Apply combination (salicylic acid and coal tar) shampoo to scalp evenly before bathing.^u Allow to remain on scalp for 5 minutes and then rinse thoroughly.^u Gradually increase treatment times to 1 hour, or as directed by a clinician.^u Alternatively, apply to wet hair; allow to remain on scalp for up to 10 minutes, then rinse.^u Use daily until itching and flaking improve, then reduce to twice weekly or as directed by a clinician.^u

Body (Excluding Scalp)

Topical

Self-medication: Apply appropriate 1.8–3% salicylic acid preparation (e.g., cream, ointment, lotion, gel) to affected area(s) 1–4 times daily or as directed by a clinician.^{f q r}

Self-medication: Apply 2–3% salicylic acid shampoo to affected area(s) of the body in place of soap.^m Leave lather on for 2 minutes, then rinse thoroughly; repeat if necessary.^m Use at least twice weekly or as directed by a clinician.^{f m}

Apply 6% salicylic acid gel, cream, or lotion to affected area(s) once daily at bedtime and occlude.^{l o p} When improvement occurs, apply occasionally to maintain remission.^{l o p} In areas where occlusion is difficult or impossible, apply more frequently.^{l o p}

Hyperkeratosis

Corn and/or Callus Removal

Topical

Self-medication: Apply 12–40% salicylic acid plaster to corn or callus and cover with cushion provided by manufacturer.^{e i} After 48 hours, remove cushion and plaster.^{e i} May cover with cushion provided by manufacturer.ⁱ Repeat every 48 hours as needed until corn or callus is removed, for up to 14 days.^{e i}

Self-medication: Apply 12–17.6% salicylic acid solution or gel in flexible collodion (e.g., 1 drop at a time) to sufficiently cover corn or callus.^{e n} Repeat once or twice daily as needed for up to 14 days.^{e n}

Self-medication: Apply 3% salicylic acid gel to calloused skin once daily or as directed by a clinician. ^t

Apply 6% salicylic acid gel, cream, or lotion to the affected area(s) at bedtime and occlude.^{l o p} In areas where occlusion is difficult or impossible, apply more frequently.^{p o}

Wart Removal

Topical

Self-medication: Apply 12–40% salicylic acid plaster to wart.^d After 48 hours, remove and repeat as needed until wart is completely removed or for up to 12 weeks.^d

Self-medication: Apply 5–17% salicylic acid solution or gel in flexible collodion (e.g., 1 drop at a time) to sufficiently cover wart(s).^{d h} Repeat once or twice daily for up to 12 weeks.^{d h}

Apply 15% salicylic acid plaster in a karaya gum and polyethylene glycol vehicle to wart(s) once daily at bedtime; leave in place for ≥8 hours, then remove and discard.^{d j} Repeat every 24 hours as needed until wart is completely removed for up to 12 weeks.^{d j}

Tinea Versicolor

Topical

Self-medication: Apply combination lotion (salicylic acid 1% and sodium thiosulfate 25%) in a thin film to affected areas twice daily or as directed by a clinician.^g

Prescribing Limits

Pediatric Patients

Acne

Topical

Self-medication: Apply a maximum 3 times daily.^c

Seborrheic Dermatitis and Psoriasis

Scalp

Topical

Self-medication for children >2 years of age: Apply 3% salicylic acid solution a maximum 4 times daily or as directed by a clinician.^{f s}

Body (Excluding Scalp)

Topical

Self-medication for children >2 years of age: Apply appropriate 1.8–3% salicylic acid preparation (e.g., cream, lotion, ointment, gel) a maximum 4 times daily or as directed by a clinician.^f

Adults

Acne

Topical

Self-medication: Apply a maximum 3 times daily.^c

Seborrheic Dermatitis and Psoriasis

Scalp

Topical

Self-medication: Apply 3% salicylic acid solution for a maximum 4 times daily or as directed by a clinician.^{f s}

Body (Excluding Scalp)

Topical

Self-medication: Apply appropriate 1.8–3% salicylic acid preparation (e.g., cream, lotion, ointment, gel) a maximum 4 times daily or as directed by a clinician.^f

Hyperkeratosis

Corn and/or Callus Removal

Topical

Self-medication: Apply plaster or solution or gel in flexible collodion a maximum 14 days.^{e i n}

Wart Removal

Topical

Self-medication: Apply plaster or solution or gel in flexible collodion a maximum 12 weeks.^{d h j}

Special Populations

Hepatic Impairment

No specific dosage recommendations at this time; however, manufacturer recommends that treatment area should be limited.^{l o}

Renal Impairment

No specific dosage recommendations at this time; however, manufacturer recommends that treatment area should be limited.^{l o}

Cautions for Salicylic Acid

Contraindications

• 
  

  Known sensitivity to salicylic acid or any other ingredient in the formulation.^{l o}

  
  


• 
  

  6% salicylic acid cream, lotion, and gel: Children <2 years of age.^{l o}

  
  

Warnings/Precautions

Warnings

Salicylate Toxicity

Risk of salicylate toxicity (e.g., nausea, vomiting, dizziness, loss of hearing, tinnitus, lethargy, hyperpnea, diarrhea, psychic disturbances) after prolonged or excessive topical use over large areas.^{l o p} If salicylic acid toxicity occurs, immediately discontinue; administer fluids to promote urinary excretion, and administer sodium bicarbonate (oral or IV) if clinically necessary.^{l o}

Avoid other salicylates (e.g., aspirin, salicylate athletic creams) to minimize exposure to salicylic acid.^{l o} (See Interactions under Cautions.)

Use of Fixed Combinations

When used in fixed combination with urea, coal tar, and sodium thiosulfate, consider the cautions, precautions, and contraindications associated with these agents.^{g u}

General Precautions

Topical Effects

Possible excessive erythema or scaling if applied to open skin lesions.^{l o p}

If excessive burning, irritation, stinging, or peeling occurs, discontinue use and consult a clinician.^{g o}

Possible necrosis of normal skin with overuse.^a

Concomitant Illnesses

Do not use salicylic acid wart, corn, and callus removal preparations in patients with diabetes or with poor blood circulation.^{d h n}

Specific Populations

Pregnancy

Category C.^{l o}

Lactation

Discontinue nursing or the drug.^{l o} If used by nursing women, avoid applying to the chest area.^l

Pediatric Use

Salicylic acid 6% cream, lotion, and gel and 15% plaster not recommended in children <2 years of age.^{l j o} (See Contraindications.)

Increased risk of salicylate toxicity with prolonged, excessive use in children <12 years of age.^{l o} Limit treatment area and monitor for possible signs of salicylate toxicity.^{l o} (See Salicylate Toxicity under Cautions.)

Use of salicylates in children with varicella infection or influenza-like illnesses reportedly is associated with an increased risk of developing Reye’s syndrome.^{b l o} US Surgeon General, AAP Committee on Infectious Diseases, FDA, and other authorities advise that salicylates not be used in children and teenagers with varicella or influenza, unless directed by a clinician.^{b l o}

Hepatic Impairment

Possible salicylate toxicity after prolonged topical use over large areas, especially in patients with substantial hepatic impairment.^{l o p} Limit treatment area and monitor for possible signs of salicylate toxicity.^{l o} (See Salicylate Toxicity under Cautions.)

Renal Impairment

Possible salicylate toxicity after prolonged topical use over large areas, especially in patients with substantial renal impairment.^{l o p} Limit treatment area and monitor for possible signs of salicylate toxicity.^{l o} (See Salicylate Toxicity under Cautions.)

Common Adverse Effects

Erythema,^{l o p} scaling,^{l o p} burning,^{g o} stinging,^{g o} peeling.^c

Interactions for Salicylic Acid

Topical Acne Preparations

Cumulative irritant or drying effect.^{c k} If excessive dryness occurs, use only one topical medication unless directed by a clinician.^c

Topical Salicylate Preparations

Increased risk of salicylate toxicity.^{l o}

Protein-bound Drugs

Potential for salicylate to displace or to be displaced by other protein-bound drugs.^{b l o}

Specific Drugs

Drug	Interaction	Comments
Acidifying agents	Drugs that decrease urine pH may decrease salicylate excretionl
Anticoagulants (warfarin, heparin)	Increased risk of bleedingb l o May displace warfarin from protein-binding sites, leading to prolongation of PT and bleeding timeb l o
Antidiabetic agents (sulfonylureas)	Potential for increased hypoglycemic effectb l o
Aspirin	Increased risk of salicylate toxicityl	Avoid concomitant usel
Corticosteroids	Decreased plasma salicylate concentrationsb Potential increased plasma salicylate concentrations and salicylate toxicity when corticosteroids are discontinuedb l o
Diuretics	Increased plasma salicylate concentrationsl o
Methotrexate	Possible increased methotrexate toxicity because of displacement from protein binding sitesb l o
Pyrazinamide	Possible prevention or reduction of hyperuricemia associated with pyrazinamideb l o
Sulfur	Possible synergistic keratolytic effecta
Uricosuric agents (probenecid, sulfinpyrazone)	Reduced uricosuric effect of uricosuric agentsb l o

Salicylic Acid Pharmacokinetics

Absorption

Bioavailability

Rapidly and well absorbed percutaneously following topical application.^{b l}

Following topical application of salicylic acid 6% gel, >60% absorbed, with peak plasma concentration usually attained within 5 hours (under occlusion).^{l o}

Onset

In vitro, plaster (Trans-Ver-Sal) released about 16, 48, 65, 79, 89, and 100% of the salicylic acid dose by 0.5, 1, 2, 4, 8, and 24 hours, respectively.^a

Plasma Concentrations

Following topical application of salicylic acid 6% gel, peak serum salicylate concentrations were <50 mcg/mL; concentrations >300 mcg/mL generally associated with salicylate toxicity.^{l o}

Distribution

Extent

Distributed in extracellular space.^{l o}

Plasma Protein Binding

50–80%.^{l o}

Special Populations

Patients with a contracted extracellular space secondary to dehydration or diuretics may have increased plasma salicylate levels.^{l o}

Elimination

Elimination Route

Excreted principally in urine as salicyluric acid (52%), salicylate glucuronides (42%), and free salicylic acid (6%).^{l o}

Stability

Storage

Topical

Cream, Lotion

20–25°C.^l Do not freeze.^l

Store combination lotion (salicylic acid 1% and sodium thiosulfate 25%) at 15–30°C.^g

Solution

Solution in flexible collodion: Tightly closed containers at 15–30°C.^a Flammable; keep away from heat and open flame.^{a d e}

Gel

Tightly closed containers at 15–30°C.^{a p}

Gel in flexible collodion: Tightly closed containers at 15–30°C.^a Flammable, keep away from heat and open flame.^{a d e}

Shampoo

Salicylic acid 3%: Tightly closed containers; avoid excessive heat or cold.^m

Plaster

Well-closed containers at 15–30°C.^a

ActionsActions

• 
  

  Exact mechanism(s) of action not elucidated; appears to soften and destroy the stratum corneum by increasing endogenous hydration that causes the cornified epithelium (horny layer) of the skin to swell, soften, and desquamate.^{a j l o}

  
  


• 
  

  In low concentrations, has keratoplastic activity (correction of abnormal keratinization); at concentrations ≥1%, has keratolytic activity (causes peeling of skin); and at concentrations ≥20%, has a caustic effect.^a

  
  


• 
  

  Has weak antifungal and antibacterial activity.^a

  
  


• 
  

  May promote the penetration of other active ingredients and have a comedolytic effect.^a

  
  


• 
  

  Requires moisture to exert its action on the skin and for maceration and desquamation of epidermal tissue.^a

  
  

Advice to Patients

• 
  

  Importance of keeping salicylic acid preparations out of reach of children.^{g m o}

  
  


• 
  

  Importance of avoiding heat or flames during use of certain salicylic acid collodion formulations.^{n o}

  
  


• 
  

  For external use only.^o Importance of avoiding contact with eyes.^{k n q r}

  
  


• 
  

  Importance of rinsing hands thoroughly after topical application, unless hands are being treated.^{l o p}

  
  


• 
  

  Advise patients that salicylic acid topical preparations used concurrently with other topical medications may increase skin dryness or irritation.^c

  
  


• 
  

  Importance of not using for prolonged periods of time for self-medication of dandruff, seborrheic dermatitis, or psoriasis; importance of consulting a clinician if the condition worsens or does not improve after regular use.^f

  
  


• 
  

  Advise patients that, when salicylic acid preparations are used for wart removal, visible improvement generally occurs during the first several days of treatment and complete removal may require 3–12 weeks of use.^j

  
  


• 
  

  Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.^{l o p}

  
  


• 
  

  Importance of patients informing clinician of existing or contemplated concomitant therapy, including prescription and OTC drugs.^{l o}

  
  


• 
  

  Importance of informing patients of other important precautionary information. (See Cautions.) ^o

  
  

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Salicylic Acid

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Bulk	Powder*
Topical	Cake	0.5%	Aveeno Clear Complexion Cleansing Bar	Johnson & Johnson
			Oxy Bar Soap	Mentholatum
		2%	Salicylic Acid Cleansing Bar	Stiefel
	Cleansing Cream	2%	Clearasil Oil Control Cream Cleanser	Reckitt Benckiser
			Clearasil StayClear Skin Perfecting Wash	Reckitt Benckiser
	Cleansing Pledgets (saturated with solution)	0.5%	Oxy Daily Cleansing Pad (with alcohol 34%)	Mentholatum
			Stridex Sensitive Skin Pads (with SD alcohol 28% and aloe)	Blistex
		1%	Stridex Essential Care Pads	Blistex
		2%	Clearasil StayClear Acne Fighting Cleansing Wipes	Reckitt Benckiser
			Clearasil StayClear Daily Pore Cleansing Pads	Reckitt Benckiser
			Clearasil Ultra Deep Pore Cleansing Pads (with propylene glycol and parabens)	Reckitt Benckiser
			Noxzema Triple Clean Pads (with SD-alcohol 40)	Procter & Gamble
			Oxy Blackhead Pads (with alcohol 46%)	Mentholatum
			Oxy Daily Cleansing Pads (with alcohol 46%)	Mentholatum
			Oxy Maximum Cleansing Pads (with alcohol 46%)	Mentholatum
			Stridex Pads Maximum Strength (with SD alcohol 40 44%)	Blistex
	Cleansing Solution	2%	Noxzema Triple Clean Blackhead Cleanser	Proctor & Gamble
			Oxy Body Wash (with parabens and propylene glycol)	Mentholatum
			Oxy Face Wash	Mentholatum
	Cleansing Suspension	2%	Clearasil StayClear Daily Facial Scrub	Reckitt Benckiser
			Oxy Maximum Face Scrub (with parabens and propylene glycol)	Mentholatum
	Cream	6%	Salex (with parabens)	Coria
	Gel	1%	Clearasil Blackhead Control	Reckitt Benckiser
		2%	Neutrogena Rapid Clear Acne Eliminating (with propylene glycol)	Neutrogena
			Stridex Clear Gel Maximum Strength (with SD alcohol 9.3%)	Blistex
		3%
		Dermarest Psoriasis Medicated Scalp Treatment (with SD alcohol 40, propylene glycol, and parabens)	Del
			Dermarest Psoriasis Medicated Skin Treatment (with parabens and propylene glycol)	Del
			Keralyt (with SD-40 alcohol 21% and propylene glycol)	Summers
		6%	Hydrisalic (with SD alcohol 40B and propylene glycol)	Pedinol
			Keralyt (with SD-40 alcohol 21% and propylene glycol)	Summers
		17%	Sal-Plant Gel (with isopropyl alcohol 2.5% in flexible collodion)	Pedinol
		17.6%	Compound W Gel (with alcohol 67.5% in flexible collodion)	Prestige
	Lotion	2%	Dermarest Psoriasis Medication Moisturizer (with parabens)	Del
			Sebasorb (with attapulgite activated, acetyl alcohol, and propylene glycol)	Summers
		6%	Salex (with parabens)	Coria
	Ointment	3%	MG 217 Sal-Acid	Triton
	Plaster	15%	Trans-Ver-Sal (with karaya and propylene glycol)	Doak
		40%	Compound W One Step Invisible Strips	Prestige
			Compound W One Step Pads	Prestige
			Curad Mediplast	Beiersdorf
			Dr Scholl’s Callus Remover	Schering-Plough
			Dr Scholl’s Clear Away Medicated Disk	Schering-Plough
			Dr Scholl’s Clear Away One-Step Invisible Strips	Schering-Plough
			Dr Scholl’s Clear Away Plantar for Feet	Schering-Plough
			Sal-Acid	Pedinol
	Shampoo	2%	Ionil Plus (with SD alcohol 40 12%)	Healthpoint
			P&S (with methylparaben and propylparaben)	Aero
		3%	Denorex Extra Strength Shampoo (with propylene glycol)	Prestige
			DHS Sal Shampoo	Person & Covey
			Neutrogena T/Sal Maximum Strength	Neutrogena
			Psoriasin Therapeutic Shampoo & Body Wash	Alva-Amco Pharmacal
	Solution	2%	Noxzema 2-in-1 Astringent (with SD-alcohol 40)	Procter & Gamble
			Noxzema Continuous Clean Clarifying Toner	Procter & Gamble
		3%	Dermarest Psoriasis Medicated Overnight Treatment	Del
		16.7%	Gordofilm (in flexible collodion)	Gordon
		17%	Dr Scholl’s Clear Away Fast Acting Liquid (with SD alcohol 32 17% and ether 52% in flexible collodion)	Schering-Plough
			Dr Scholl’s Liquid Corn/Callus Remover (with alcohol SD 32 18% and ether 53% in flexible collodion)	Schering-Plough
			DuoFilm (with alcohol SD 32 17% and ether 52% in flexible collodion)	Schering-Plough
			Occlusal-HP (with isopropyl alcohol 63% in polyacrylic vehicle)	Bioglan
			Salactic Film (with isopropyl alcohol 2.7% in flexible collodion)	Pedinol
			Wart-Off (with alcohol 26.35% in flexible collodion)	Pfizer
		17.6%	Compound W Liquid (with alcohol 21.2% and ether 63.6% in flexible collodion)	Prestige
			Freezone (with alcohol 33% and ether 65.5% in flexible collodion)	Prestige

Salicylic Acid Combinations

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Topical	Lotion	1% with Sodium Thiosulfate 25%	Versiclear (with propylene glycol)	Hope
	Ointment	5% with Urea 10%	Kerasal Foot Ointment	Alterna
	Shampoo	3% with Coal Tar Solution 10% (equivalent to 2% coal tar)	Tarsum	Summers
		3% with Colloidal Sulfur 5%	Meted	DUSA

Comparative Pricin